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Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to reproductive system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Penile freckling
Varicocele
Hydrocele testis
Prostate cancer
Ovarian cyst
Dysgerminoma
Ovarian carcinoma
Ovarian papillary adenocarcinoma
Uterine neoplasm
Disease(s) Associated with PTEN
Bannayan-Riley-Ruvalcaba syndrome
macrocephaly-autism syndrome
ovarian cancer
prostate cancer

Mouse Phenotypes
reproductive system phenotype
abnormal oocyte morphology
decreased granulosa cell apoptosis
impaired luteal cell differentiation
increased granulosa cell proliferation
abnormal maternal decidual layer morphology
decreased uterine NK cell number
abnormal mammary gland growth during pregnancy
abnormal prostate gland morphology
enlarged prostate gland anterior lobe
prostate gland anterior lobe hyperplasia
prostate gland dorsolateral lobe hyperplasia
abnormal prostate gland epithelium morphology
prostate gland epithelial hyperplasia
increased prostate gland weight
enlarged prostate gland
prostate gland hyperplasia
abnormal seminal vesicle morphology
abnormal corpus luteum morphology
increased corpora lutea number
abnormal ovarian follicle morphology
decreased primordial ovarian follicle number
absent primordial ovarian follicles
abnormal ovarian folliculogenesis
abnormal primordial ovarian follicle morphology
enlarged ovary
abnormal seminiferous tubule morphology
increased granulosa cell tumor incidence
increased prostate gland tumor incidence
increased prostate gland adenocarcinoma incidence
increased prostate intraepithelial neoplasia incidence
abnormal prostate gland physiology
prostate gland inflammation
abnormal ovary physiology
premature ovarian failure
increased endometrial carcinoma incidence
increased uterus carcinoma incidence
abnormal reproductive system morphology
abnormal uterus morphology
abnormal endometrium morphology
endometrium fibrosis
endometrium hyperplasia
abnormal myometrium morphology
decreased uterus weight
increased uterus weight
uterus hyperplasia
abnormal epididymis epithelium morphology
abnormal vas deferens morphology
increased superovulation rate
abnormal estrous cycle
abnormal luteolysis
abnormal pregnancy
abnormal uterus physiology
female infertility
reduced female fertility
decreased litter size
enhanced female fertility
reduced fertility
Availability Mouse Genotype
Ptentm1.1Yxy/Ptentm1.1Yxy *
Ptentm1.1Gle/Pten+
Ptentm1.1Hwu/Pten+
Ptentm1.2Mwst/Pten+
Ptentm1Mak/Pten+
Ptentm1Ppp/Ptentm2Ppp
Ptentm1Rps/Pten+
Ptentm2.1Gle/Pten+
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Cnptm1(cre)Kan/Cnp+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh16-cre)91Igr/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp1-cre)1Jig/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0  (conditional)
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Zp3-cre)93Knw/0  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre)1Dcas/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre/ERT2)1Dcas/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/?  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Amhr2tm3(cre)Bhr/Amhr2+  (conditional)
*
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Amhr2tm3(cre)Bhr/Amhr2+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
*
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)#Tfln/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)20Fwan/?  (conditional)
Ptentm1Mro/Ptentm1Mro
Tg(KLK3-cre)D4Trp/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)8113ANg/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Osr1-cre)4Mrt/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Cyp1a1-cre)1Dwi/0  (conditional)
Hprt1tm1(Pbsn*-cre/ERT2)Jir/Y
Ptentm2Mak/Ptentm2Mak  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(KLK3-cre)13Saa/0  (conditional)
Ptentm1Hwu/Pten+
Tg(Pbsn-cre)4Prb/0  (conditional)
Ptentm1Mro/Pten+
Tg(KLK3-cre)D4Trp/0  (conditional)
Ptentm1Mro/Pten+
Tg(Pbsn-cre)4Prb/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory